A9528
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A9528
Sigma
Amphotericin B solubilized
powder, γ-irradiated, cell culture tested
| Synonym: | Amphotericin B from Streptomyces sp., Fungizone |
| CAS Number: | 1397-89-3 |
| Linear Formula: | C47H73NO17 |
| Molecular Weight: | 924.08 |
| Beilstein Registry Number: | 78342 |
| MDL number: | MFCD00877763 |
| PubChem Substance ID: | 24891468 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Application | Recommended for use in cell culture applications at 5.6 mg (solid)/L. |
| Biochem/physiol Actions | Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast. |
| Mode of Action: Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. | |
| Packaging | Package size based on amphotericin B |
Properties
| sterility | γ-irradiated |
| form | powder |
| solubility | sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20 °C. Stable at 37 °C for 3 days. |
| suitability | cell culture tested |
| storage temp. | 2-8°C |
Safety
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
Components
| Standard component | Amphotericin B ~45% |
| Sodium deoxycholate ~35% | |
| Sodium phosphate balance |
References
| reference | Perlman, D., Use of antibiotics in cell culture media. Meth. Enzymol. LVIII, 112, (1979) |
| Merck | Merck 13,590 |
| Beilstein | Beil. 18,V,10,525 |
